P06 - Spatially resolved single cell analysis of human lung aging
Reduced resilience to environmental challenges often results in chronic lung disease (CLD), which is most prevalent in the elderly and ultimately stems from a multifactorial combination of aging, genetic predisposition, and lifelong epigenetic priming that together limit regenerative capacity of the lung. In this PhD project, the student will use spatially resolved single cell analysis methods, including multiplexed immunofluorescence and mass spec based single cell resolved deep visual proteomics (scDVP method) of cell circuits, to characterize the impact of aging associated cellular senescence on the regenerative capacity of human lung tissue.
This project will be part of a multimodal human lung aging atlas, which will deepen our understanding of the aging process and its intersection with CLD, potentially enabling future pro-regenerative therapies that lengthen the lungs´ healthspan in our aging society.
Dr. Herbert SchillerInstitute of Lung Biology and Disease (ILBD) Comprehensive Pneumology Center (CPC) +49 89 3187-1194 |