RTG 2338 Targets in Toxicology
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Publications

2024

Gölitz F, Herbert J, Worek F, Wille T. AChE reactivation in precision-cut lung slices following organophosphorus compound poisoning. Toxicology Letters 392 (2024) 75–83. [Project P02]

2023

 

Staab-Weijnitz CA, Onursal C, Nambiar D, Vanacore R. Assessment of Collagen in Translational Models of Lung Research. Adv Exp Med Biol. 2023;1413:213-244. doi: 10.1007/978-3-031-26625-6_11. PMID: 37195533
[Project P07]

Beck C, Ramanujam D, Vaccarello P, Widenmeyer F, Feuerherd M, Cheng CC, Bomhard A, Abikeeva T, Schädler J, Sperhake JP, Graw M, Safi S, Hoffmann H, Staab-Weijnitz CA, Rad R, Protzer U, Frischmuth T, Engelhardt STrimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage.
Nat Commun. 2023 Jul 28;14(1):4564. doi: 10.1038/s41467-023-40185-1. PMID: 37507393
[Project P07 & P09]

Nakayama M, Marchi H, Dmitrieva AM, Chakraborty A, Merl-Pham J, Hennen E, Le Gleut R, Ruppert C, Guenther A, Kahnert K, Behr J, Hilgendorff A, Hauck SM, Adler H*, Staab-Weijnitz CA*. Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection. Front Microbiol, 2023 Jan 11. 13:957830. doi: 10.3389/fmicb.2022.957830 *co-corresponding authors [Project P07 & P05]

Müller-Dott K, Raßmuß SK, Blum MM, Thiermann H, John H, Steinritz DActivation of the human TRPA1 channel by different alkylating sulfur and nitrogen mustards and structurally related chemotherapeutic drugs. Toxicology Letters, Volume 376, 2023, Pages 51-59, ISSN 0378-4274. [Project P03]

2022

Geiger F, Zeitlmayr S, Staab-Weijnitz CA, Rajan S, Breit A, Gudermann T, Dietrich A. (2022). An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast to Myofibroblast Differentiation. Am J Respir Cell Mol Biol, 2022 Nov 15.doi: 10.1165/rcmb.2022-0159OC. [Project P04 & P07 & P10]

Schmidt E, Narangoda C, Nörenberg W, Egawa M, Rössig A, Leonhardt M, Schaefer M, Zierler S, Kurnikova MG, Gudermann T, Chubanov V. Structural mechanism of TRPM7 channel regulation by intracellular magnesium. Cell Mol Life Sci. 2022 Apr. 7;79(5):225. doi: 10.1007/s00018-022-04192-7. IF: 9,26. [Project P10]

Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G. Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection. J Clin Invest. 2022 Jul 1;132(13):e150951. doi: 10.1172/JCI150951 [Project P10]

Rios F, Zou Z-G, Harvey A, Harvey K, Camargo L, Neves K, Nichol S, Alves-Lopes R, Cheah A, Zahraa M, Ryazanov A, Ryazanova L, Gudermann T, Chubanov V, Montezano A, Touyz R. TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Commun. Biol. Jul 2022. DOI: 10.1038/s42003-022-03715-z [Project P10]

Heydarian M, Oak P, Zhang X, Kamgari N, Kindt A, Koschlig M, Pritzke T, Gonzalez-Rodriguez E, Förster K, Morty RE, Häfner F, Hübener C, Flemmer AW, Yildirim AO, Sudheendra D, Tian X, Petrera A, Kirsten H, Ahnert P, Morrell N, Desai TJ, Sucre J, Spiekerkoetter E, Hilgendorff A. Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant. Thorax. 2022 May 17;thoraxjnl-2021-218083. doi: 10.1136/thoraxjnl-2021-218083 [Project P05 & P06]

Zeitlmayr S, Zierler S, Staab-Weijnitz C, Dietrich A, Geiger F, Horgen D, Gudermann T and Breit A. TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts. Arch. Toxicol. Jul 2022. DOI 10.1007/s00204-022-03342-x [Project P04, P07 and P10]

Kazandzhieva K, Mammadova-Bach E, Dietrich A, Gudermann T, Braun A. TRP channel function in platelets and megakaryocytes: basic mechanisms and pathophysiological impact. Pharmacol Ther. 2022 Mar 3;237:108164. doi: 10.1016/j.pharmthera.2022.108164. Online ahead of print. PMID: 35247518 Review. IF: 12,31. [Project P04  P10]

Schmidt E, Narangoda C, Nörenberg W, Egawa M, Rössig A, Leonhardt M, Schaefer M, Zierler S, Kurnikova MG, Gudermann T, Chubanov V. Structural mechanism of TRPM7 channel regulation by intracellular magnesium. Cell Mol Life Sci. 2022 Apr. 7;79(5):225. doi: 10.1007/s00018-022-04192-7. IF: 9,26 [Project P10]

Preisendörfer S, Ishikawa Y, Hennen E, Winklmeier S, Schupp JC, Knüppel L, Fernandez IE, Binzenhöfer L, Flatley A, Juan-Guardela BM, Ruppert C, Guenther A, Frankenberger M, Hatz RA, Kneidinger N, Behr J, Feederle R, Schepers A, Hilgendorff A, Kaminski N, Meinl E, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. FK506-binding protein 11 is a novel plasma cell-specific antibody folding catalyst with increased expression in idiopathic pulmonary fibrosis. Cells 2022 Apr, 11(8), 1341; doi: 10.3390/cells11081341. [Project P05 & P07]

Krick S, Geraghty P, Jourdan Le Saux C, Rojas M, and Staab-Weijnitz CA. Editorial: Defining and Characterizing Respiratory Disease in an Aging Population. Frontiers in Medicine 2022 Apr, 9:889834. doi: 10.3389/fmed.2022.889834. [Project P07]

Tigges J, Worek F, Thiermann H, Wille T. Organophosphorus pesticides exhibit compound specific effects in rat precision cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative. Arch Toxicol. 2022 Jan;96(1):321-334. [Project P02]

Schremmer C, Steinritz D, Gudermann T, Beech DJ, Dietrich A. An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (-)-englerin A. Arch Toxicol. 2022 Feb 14. doi: 10.1007/s00204-022-03235. [Project P03, P04 & P10]

Staab-Weijnitz CA. Fighting the Fiber: Targeting Collagen in Lung Fibrosis (Translational Review). Am J Resp Cell Mol Biol, in press. 2022. doi: 10.1165/rcmb.2021-0342TR. [Project P07]

Chakraborty A, Mastalerz M, Ansari M, Schiller HB and Staab-Weijnitz CA. Emerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis. Cells 2022, 11(6), 1050. [Project P06 & P07]

Spix B, Ansari M, Yildirim AÖ, Schiller H, Grimm C#. Endolysosomal cation channels and lung disease. Cells (1(2):304, 2022. Review Article. [Project P06, P08 & P10]

Spix B, Butz ES, Chen C-C, Scotto Rosato A, Tang, R, Jeridi A, Kudrina, V., Plesch E, Wartenberg P, Arlt E, Briukhovetska D, Ansari M, Günes Günsel G, Conlon TM, Wyatt A, Wetzel S, Teupser D, Holdt LM, Ectors F, Boekhoff I, Boehm U, García Añoveros J, Saftig P, Giera M, Kobold S, Schiller HB, Zierler S, Gudermann T, Wahl-Schott C, Bracher F, Yildirim AÖ, Biel, M, Grimm C#. Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nature Commun 13(1):318, 2022. [Project P06, P08 & P10]

Esfandyari D, Idrissou B. M G, Hennis K, Avramopoulos P, Dueck A, El-Battrawy I, Grüter L, Meier M A, Näger A C, Ramanujam D, Dorn T, Meitinger T, Hagl C, Milting H, Borggrefe M, Fenske S, Biel M, Dendorfer A, Sassi Y, Moretti A & Engelhardt S. MicroRNA-365 regulates human cardiac action potential duration. Nat. Commun. 13, (2022). [Project P08 & P09]

Webert L, Faro D, Zeitlmayr S, Gudermann T, Breit A. Analysis of the Glucose-Dependent Transcriptome in Murine Hypothalamic Cells. Cells 2022, 11, 639. [Project P10]

Keshavarz M, Faraj Tabrizi S, Ruppert AL, Pfeil U, Schreiber Y, Klein J, Brandenburger I, Lochnit G, Bhushan S, Perniss A, Deckmann K, Hartmann P, Meiners M, Mermer P, Rafiq A, Winterberg S, Papadakis T, Thomas D, Angioni C, Oberwinkler J, Chubanov V, Gudermann T, Gärtner U, Offermanns S, Schütz B, Kummer W. Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters. Sci Immunol. 2022 Mar 4;7(69):eabf6734. doi: 10.1126/sciimmunol.abf6734. Epub 2022 Mar 4. PMID: 35245090. [Project P10]

2021

Tsetlin V, Haufe Y, Safronova V, Serov D, Shadarmarshan P, Son L, Shelukhina I, Kudryavtsev D, Kryukova E, Kasheverov I, Nicke A, Utkin YN. Interaction of α9α10 nicotinic receptors with peptides and proteins from animal venoms. Frontiers in Cellular Neuroscience. 2021 Dec 2, 15:765541. [Project P01]

Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Moller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M. Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling. Arch Toxicol. 2021 Oct 10. [Project P01]

Giribaldi J, Haufe Y, Evans ERJ, Wilson DT, Daly NL, Enjalbal C, Nicke A, Dutertre S. Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel alpha-Conotoxin with an Extended N-Terminal Tail. Mar Drugs. 2021 Mar 2;19 (3). [Project P01]

Tigges J, Eggerbauer F, Worek F, Thiermann H, Rauen U, Wille T. Optimization of long-term cold storage of rat precision cut lung slices (PCLS) with a tissue preservation solution. Am J Physiol Lung Cell Mol Physiol 2021 Dec 1;321(6):L1023-L1035. doi.org/10.1152/ajplung.00076.2021. [Project P02 & P03]

Schmeißer W, Lüling R, Steinritz D, Thiermann H, Rein T, John H. Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization. Drug Test Anal. 2021 Aug 16. doi: 10.1002/dta.3146. Online ahead of print. PMID: 34397154. [Project P03]

Steinritz D, Lüling R, Siegert M, Herbert J, Mückter H, Taeger CD, Gudermann T, Dietrich A, Thiermann H, John H. Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study. Arch Toxicol. 2021 Apr;95(4):1323-1333. doi: 10.1007/s00204-021-03005-3. Epub 2021 Feb 26. PMID: 33635393. [Project P03, P04 & P10]

Steinritz D, Lüling R, Siegert M, Mückter H, Popp T, Reinemer P, Gudermann T, Thiermann H, John H. Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro. Arch Toxicol. 2021 Oct;95(10):3253-3261. doi: 10.1007/s00204-021-03137-6. Epub 2021 Aug 16. PMID: 34396457. [Project P03 & P10]

Rajan S, Schremmer C, Weber J, Alt P, Geiger F, Dietrich A. Ca2+ signaling by TRPV4 channels in respiratory function and disease. Cells 10:822, doi: 10.3390/cells10040822, 2021. [Project P04]

Mastalerz M, Dick E, Chakraborty A, Hennen E, Schamberger AC, Schröppel A, Lindner M, Hatz R, Behr J, Hilgendorff A, Schmid O, Staab-Weijnitz CA. Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2022 Jan 1;322(1):L129-L148. doi: 10.1152/ajplung.00091.2021. Epub 2021 Oct 20. PMID: 34668416. [Project P05, P06 & P07]

Sucre J, Haist L, Bolton CE, Hilgendorff A. Early Changes and Indicators Characterizing Lung Aging in Neonatal Chronic Lung Disease. Front Med (Lausanne). 2021 May 31;8:665152. doi: 10.3389/fmed.2021.665152. PMID: 34136503; PMCID: PMC8200413. [Project P05]

Förster K, Haist L, Hilgendorff A. Langzeitfolgen der chronischen neonatalen Lungenerkrankung: Frühe Veränderungen und spätere Indikatoren. InFo Pneumologie & Allergologie. 2021, Vol. 3, Nr. 2. [Project P05]

Onursal C, Dick E, Angelidis I, Schiller HB, and Staab-Weijnitz CA. Collagen biosynthesis, processing and maturation in lung ageing. Frontiers in Medicine, available online. doi: 10.3389/fmed.2021.593874. [Project P06 & P07]

Ramanujam D, Schön AP, Beck C, Vaccarello P, Felician G, Dueck A, Esfandyari D, Meister G, Meitinger T, Schulz C, Engelhardt S. et al. MiR-21-dependent macrophage-to-fibroblast signaling determines the cardiac response to pressure overload. Circulation 143, 1513–1525 (2021). [Project P09]

Kollewe A, Chubanov V, Tseung FT, Correia L, Schmidt E, Rössig A, Zierler S, Haupt A, Müller CS, Bildl W, Schulte U, Nicke A, Fakler B, Gudermann T. The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics. Elife. 2021 Nov 12;10:e68544. doi: 10.7554/eLife.68544. Online ahead of print. PMID: 34766907. [Project P04 & P10]

Behrend SJ, Giotopoulou GA, Spella M, Stathopoulos GT. A role for club cells in smoking-associated lung adenocarcinoma. Eur Respir Rev 2021;30:210122. [Project P11]

Lamort AS*#, Kaiser JC*#, Pepe MAA, Lilis I, Ntaliarda G, Somogyi K, Spella M, Behrend SJ, Giotopoulou GA, Kujawa W, Lindner M, Koch I, Hatz RA, Behr J, Sotillo R, Schamberger AC, Stathopoulos GT*#. Prognostic phenotypes of early-stage lung adenocarcinoma. European Respiratory Journal 2021; DOI: 10.1183/13993003.01674-2021. [Project P06 & P11]

Spella M, Stathopoulos GT. Immune Resistance in Lung Adenocarcinoma. Cancers (Basel) 2021;13:384. [Project P11]

Schelter F, Kirchner A, Traube FR, Müller M, Steglich W, Carell T. 5-Hydroxymethyl-, 5-Formyl- and 5-Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks. Chem. Eur. J. 2021; 27(31):8100-8104. doi:10.1002/chem.202100551. [Project P12]

Müller N, Ponkkonen E, Carell T, Khobta A. Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine. Int J Mol Sci. 2021;22(20):11025. Published 2021 Oct 13. doi:10.3390/ijms222011025. [Project P12]

2020

Giribaldi J*, Haufe Y*, Evans ERJ, Amar M, Durner A, Schmidt C, Faucherre A, Moha Ou Maati H, Enjalbal C, Molgo J, Servent D, Wilson DT, Daly NL, Nicke A, Dutertre S. Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic Receptors. J Med Chem . 2020 Nov 12;63 (21):12682-92. [Project P01]

Wilson DT, Bansal PS, Carter DA, Vetter I, Nicke A, Dutertre S, Daly NL. Characterisation of a Novel A-Superfamily Conotoxin. Biomedicines. 2020 May 20;8(5):128. [Project P01]

Tsoutsoulopoulos A, Gohlsch K, Möhle N, Breit A, Hoffmann S, Krischenowski O, Mückter H, Gudermann T, Thiermann H, Aufderheide M, Steinritz D. Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface. J Vis Exp. 2020 Feb 23;(156). doi: 10.3791/60572. PMID: 32150152. [Project P03 & P10]

Müller-Dott K, Thiermann H, Steinritz D, Popp T. Effect of sulfur mustard on melanogenesis in vitro. Toxicol Lett. 2020 Feb 1;319:197-203. doi: 10.1016/j.toxlet.2019.11.014. Epub 2019 Nov 27. PMID: 3178546. [Project P03]

Lüling R, Schmeißer W, Siegert M, Mückter H, Dietrich A, Thiermann H, Gudermann T, John H, Steinritz D. Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard. Drug Test Anal. 2021 Feb;13(2):268-282. doi: 10.1002/dta.2916. Epub 2020 Sep 18. PMID: 3285211. [Project P03, P04 & P10]

Weber J, Rajan S, Schremmer C, Chao YK, Krasteva-Christ G, Kannler M, Yildirim AÖ, Brosien M, Schredelseker J, Weissmann N, Grimm C, Gudermann T, Dietrich A. TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema. JCI Insight 5:e134464. doi: 10.1172/jci.insight.134464, 2020. [Project P04, P08 & P10]

Käsmann L, Dietrich A, Staab-Weijnitz CA, Manapov F, Behr J, Rimner A, Jeremic B, Senan S, De Ruysscher D, Lauber K, Belka C. Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review. Radiat Oncol 15:214, doi: 10.1186/s13014-020-01654-9, 2020. [Project P04, P06 & P07]

Bendiks L, Geiger F, Gudermann T, Feske S, Dietrich A. Store-operated Ca<sup>2+</sup> entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration. Sci Rep. 2020 Apr 22;10(1):6812. doi: 10.1038/s41598-020-63677-2. PMID: 32321939; PMCID: PMC7176639. [Project P04 & P10]

Spix B, Chao Y-K, Abrahamian C, Grimm C#. TRPML cation channels in inflammation and immunity (Research Topic: TRP channels in inflammation and immunity). Front Immunol, 11:225, 2020. Review Articl. [Project P08]

Voringer S, Schreyer L, Nadolni W, Meier MA, Woerther K, Mittermeier C, Ferioli S, Singer S, Holzer K, Zierler S, Chubanov V, Liebl B, Gudermann T*, Muehlich S*. Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity. Oncogene. 2020 Mar;39(11):2328-2344. doi: 10.1038/s41388-019-1140-8. Epub 2019 Dec 16. PMID: 31844251 *corresponding authors. [Project P10]

Marazioti A*, Voulgaridis A*, Psallidas I*, Lamort AS, Iliopoulou M, Krontira AC, Lilis I, Asciak R, Kanellakis NI, Rahman NM, Karkoulias K, Spiropoulos K, Kaiser JC, Stathopoulos GT. Clinical identification of malignant pleural effusions. medRxiv (2020): 2020.05.31.20118307. [Project P11]

Hu C, Meiners S, Lukas C, Stathopoulos GT, Chen J. Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Prolif 2020;53(6):e12828. [Project P11]

Giotopoulou GA, Stathopoulos GT. Effects of Inhaled Tobacco Smoke on the Pulmonary Tumor Microenvironment. Adv Exp Med Biol. 2020;1225:53-69. doi: 10.1007/978-3-030-35727-6_4. PMID: 32030647. [Project P11]

Schön A, Kaminska E, Schelter F, et al. Analysis of an Active Deformylation Mechanism of 5-Formyl-deoxycytidine (fdC) in Stem Cells. Angew Chem Int Ed Engl. 2020;59(14):5591-5594. doi:10.1002/anie.202000414. [Project P12]

2019

El Hamdaoui Y, Wu X, Clark RJ, Giribaldi J, Anangi R, Craik DJ, King GF, Dutertre S, Kaas Q, Herzig V, Nicke A. Periplasmic Expression of 4/7 alpha-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the alpha7 nAChR. Front Pharmacol. 2019 10:577. [Project P04]

Herbert J, Thiermann H, Worek F and Wille T. COPD and asthma therapeutics for supportive treatment in organophosphate poisoning. Clin Toxicol (Phila). 2019 Jul;57(7):644-651. doi: 10.1080/15563650.2018.1540785. [Project P02 & P03]

Lüling R, Singer H, Popp T, John H, Boekhoff I, Thiermann H, Daumann LJ, Karaghiosoff K, Gudermann T, Steinritz D. Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro. Arch Toxicol. 2019 Nov;93(11):3141-3152. doi: 10.1007/s00204-019-02571-x. Epub 2019 Sep 12. PMID: 31515601. [Project P03 & P10]

Gohlsch K, Mückter H, Steinritz D, Aufderheide M, Hoffmann S, Gudermann T, Breit A. Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity. Toxicol Lett. 2019 Nov;316:119-126. doi: 10.1016/j.toxlet.2019.09.014. Epub 2019 Sep 17. PMID: 31539570. [Project P03 & P10]

Steinritz D, Lang S, Popp T, Siegert M, Rothmiller S, Kranawetvogl A, Schmidt A, John H, Gudermann T, Thiermann H, Kehe K. Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines. Toxicol Lett. 2019 Oct 10;314:172-180. doi: 10.1016/j.toxlet.2019.07.023. Epub 2019 Aug 9. PMID: 31404593. [Project 03 & P10]

Tsoutsoulopoulos A, Gohlsch K, Möhle N, Breit A, Hoffmann S, Krischenowski O, Mückter H, Gudermann T, Thiermann H, Aufderheide M, Steinritz D. Validation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles. Toxicol In Vitro. 2019 Aug;58:245-255. doi: 10.1016/j.tiv.2019.03.020. Epub 2019 Mar 16. PMID: 3089035. [Project P03 & P10]

Dietrich A. Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease. Pharmaceuticals 12:23; doi:10.3390/ph12010023, 2019. [Project P04]

Merl-Pham J, Basak T, Knüppel L, Ramanujam D, Athanason M, Behr J, Engelhardt S, Eickelberg O, Hauck SM, Vanacore R, Staab-Weijnitz CA. Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an <i>in vitro</i> model of lung fibrosis. Matrix Biol Plus. 2019 Apr 13;1:100005. doi: 10.1016/j.mbplus.2019.04.002. PMID: 33543004; PMCID: PMC7852317. [Project P06, P07 & P09]

Andrault PM, Schamberger AC, Chazeirat T, Sizaret D, Renault J, Staab-Weijnitz CA, Hennen E, Petit-Courty A, Wartenberg M, Saidi A, Baranek T, Guyetant S, Courty Y, Eickelberg O, Lalmanach G, Lecaille F (2019). Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD. Am J Physiol Lung Cell Mol Physiol, 317(5):L625-L638. [Project P07]

Mittermeier L, Demirkhanyan L, Stadlbauer B, Breit A, Recordati C, Hilgendorff A, Matsushita M, Braun A, Simmons DG, Zakharian E, Gudermann T*, Chubanov V*. TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival. Proc N & <patl Acad Sci U S A. 2019 Mar 5;116(10):4706-4715. doi: 10.1073/pnas.1810633116. Epub 2019 Feb 15. PMID: 30770447 *corresponding authors. [P05 & P10]

2018

Giribaldi J, Wilson D, Nicke A, El Hamdaoui Y, Laconde G, Faucherre A, Moha Ou Maati H, Daly NL, Enjalbal C, Dutertre S. Synthesis, Structure and Biological Activity of CIA and CIB, Two alpha-Conotoxins from the Predation-Evoked Venom of Conus catus. Toxins (Basel). 2018 Jun 1;10 (6). [Project P01]

Tsoutsoulopoulos A, Siegert M, John H, Zubel T, Mangerich A, Schmidt A, Mückter H, Gudermann T, Thiermann H, Steinritz D, Popp T. A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure. Chem Biol Interact. 2019 Jan 25;298:121-128. doi: 10.1016/j.cbi.2018.11.025. Epub 2018 Nov 28. PMID: 30502332. [Project P03 & P10]