GRK 2338 Seminar - Edmund Maser
Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig-Holstein, Kiel
25.10.2019 at 16:00
Title: Aldo-Keto Reductases and Short-Chain Dehydrogenases/Reductases: Biochemistry, Physiology and Disease.
Aldo-keto reductases (AKR) and short-chain dehydrogenase/reductases (SDR) metabolise important signalling molecules such as steroid hormones, prostaglandins, biogenic amines, retinoids, and sugars. Therefore, these enzymes participate in the pathogenesis of frequent diseases including diabetes, hypertension, the metabolic syndrome, osteoporosis and cancer, and are attractive targets for therapeutic inventions. On the other hand AKR and SDR play an important role in the phase-I biotransformation of many xenobiotic drugs, toxicants and carcinogens.
After a brief introduction into the history of carbonyl reducing enzymes and the establishment of the AKR and SDR superfamilies, some relevance of these enzymes with regard to the above mentioned widespread diseases will be provided. Further, the present report focuses on recent findings in our lab on AKR and SDR enzymes, and gives some important examples of their activity towards selected pharmacologically and toxicologically relevant substrates. In addition, our results on the regulation of two human SDRs, carbonyl reductase 3 (CBR3) and 11-hydroxysteroid dehydrogenase 1 (11-HSD1), will be presented.
Time:
- 4.00 pm GRK 2338 Lecture
- 5.00 pm Meet the Speaker Session
Venue:
Pettenkoferstr. 12, D 030
Host: Thomas Gudermann (P10)
PhD-Host: Barbara Spix (P08)