RTG 2338 Targets in Toxicology

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Pierre-Marie Andrault, Andrea C Schamberger, Thibault Chazeirat, Damien Sizaret, Justine Renault, Claudia A Staab-Weijnitz, Elisabeth Hennen, Agnès Petit-Courty, Mylène Wartenberg, Ahlame Saidi, Thomas Baranek, Serge Guyetant, Yves Courty, Oliver Eickelberg, Gilles Lalmanach, and Fabien Lecaille (2019): Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD. Am J Physiol Lung Cell Mol Physiol, in press. https://doi.org/10.1152/ajplung.00061.2019 [Project P07]

Yamina El Hamdaoui, Xiaosa Wu, Richard J. Clark, Julien Giribaldi, Raveendra Anangi, David J. Craik, Glenn F. King, Sebastien Dutertre, Quentin Kaas, Volker Herzig and Annette NickePeriplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR. Front. Pharmacol., 31 May 2019. https://doi.org/10.3389/fphar.2019.00577 [Project P01]

Julia Herbert, Horst Thiermann, Franz Worek and Timo Wille. COPD and asthma therapeutics for supportive treatment in organophosphate poisoning. Clin Toxicol (Phila). 2019 Jul;57(7):644-651. doi: 10.1080/15563650.2018.1540785. [Project P02 & P03]

Merl-Pham J, Basak T, Knüppel L, Ramanujam D, Athanason M, Behr J, Engelhardt S, Eickelberg O, Hauck SM, Vanacore R, Staab-Weijnitz CA.  Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis; Matrix Biology Plus, 2019 Apr 09. https://doi.org/10.1016/j.mbplus.2019.04.002 [Project P06, P07 & P09]


Amelie Tsoutsoulopoulos, Markus Siegert, Harald John, Tabea Zubel, Aswin Mangerich, Annette Schmidt, Harald Mückter, Thomas Gudermann, Horst Thiermann, Dirk Steinritz, Tanja Popp. A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure. Chem Biol Interact. 2018 Nov 28;298:121-128. doi: 10.1016/j.cbi.2018.11.025[Project P03 & P10]