RTG 2338 Targets in Toxicology

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Dirk Steinritz, Robin Lüling, Markus Siegert, Harald Mückter, Tanja Popp, Peter Reinemer, Thomas Gudermann, Horst Thiermann & Harald JohnAlkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro. Arch Toxicol (2021). https://doi.org/10.1007/s00204-021-03137-6 [Project P02 & P03]

Ceylan Onursal, Elisabeth Dick, Ilias Angelidis, Herbert B. Schiller and Claudia A. Staab-Weijnitz. Collagen Biosynthesis, Processing, and Maturation in Lung Ageing. Front. Med., 20 May 2021. https://www.frontiersin.org/articles/10.3389/fmed.2021.593874/full [Project P07]

Florian Schelter, Angie Kirchner, Franziska R. Traube, Markus Müller, Wolfgang Steglich, Thomas Carell. 5‐Hydroxymethyl‐, 5‐Formyl‐ and 5‐Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks. Chemistry A European Journal, 26 March 2021. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202100551 [Project P12]

Julien Giribaldi, Yves Haufe, Edward R. J. Evans, David T. Wilson, Norelle L. Daly, Christine Enjalbal, Annette Nicke and Sébastien Dutertre. Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel alpha-Conotoxin with an Extended N-Terminal Tail. Mar. Drugs 2021, 19, 141. https://www.mdpi.com/1660-3397/19/3/141 [Project P01]

Deepak Ramanujam, Anna Patricia Schön, Christina Beck, Paula Vaccarello, Giulia Felician, Anne Dueck, Dena Esfandyari, Gunter Meister, Thomas Meitinger, Christian Schulz and Stefan Engelhardt. MiR-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload. Circulation, 8 Feb 2021. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050682 [Project P09]


Julien Giribaldi, Yves Haufe, Edward R. J. Evans, Muriel Amar, Anna Durner, Casey Schmidt, Adèle Faucherre, Hamid Moha Ou Maati, Christine Enjalbal, Jordi Molgó, Denis Servent, David T. Wilson, Norelle L. Daly, Annette Nicke, and Sébastien Dutertre. Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic Receptors. Journal of Medicinal Chemistry, 16 October 2020. https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00957 [Project P01]

Lukas Käsmann, Alexander Dietrich, Claudia A. Staab-Weijnitz, Farkhad Manapov, Jürgen Behr, Andreas Rimner, Branislav Jeremic, Suresh Senan, Dirk De Ruysscher, Kirsten Lauber and Claus Belka. Radiation-induced lung toxicity–cellularand molecular mechanisms ofpathogenesis, management, and literaturereview. Radiation Oncology, 10 Sep 2020. https://ro-journal.biomedcentral.com/track/pdf/10.1186/s13014-020-01654-9 [Project P04, P06 & P07]

Robin Lüling, Wolfgang Schmeißer, Markus Siegert, Harald Mückter, Alexander Dietrich, Horst Thiermann, Thomas Gudermann, Harald John, Dirk Steinritz . Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard Drug Testing and Analysis, 27 Aug 2020. https://onlinelibrary.wiley.com/doi/10.1002/dta.2916 [Project P03, P04]

Chengping Hu, Silke Meiners, Christina Lukas, Georgios T. Stathopoulos, Jie Chen. Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Proliferation, 11 May 2020. https://onlinelibrary.wiley.com/doi/full/10.1111/cpr.12828 [Project P11]


Thomas M. Wildenhof, Sarah Schiffers, Franziska R. Traube, Peter Mayer, Thomas Carell. Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5‐Aza‐2′‐deoxycytidine. Angewandte Chemie, 17 June 2019. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201904794 [Project P12]

Robin Lüling, Helena Singer, Tanja Popp, Harald John, Ingrid Boekhoff, Horst Thiermann, Lena J. Daumann, Konstantin Karaghiosoff, Thomas Gudermann & Dirk SteinritzSulfur mustard alkylates steroid hormones and impacts hormone function in vitro. Archives of Toxicology, 12 September 2019. https://link.springer.com/article/10.1007/s00204-019-02571-x [Project P03]

Pierre-Marie Andrault, Andrea C Schamberger, Thibault Chazeirat, Damien Sizaret, Justine Renault, Claudia A Staab-Weijnitz, Elisabeth Hennen, Agnès Petit-Courty, Mylène Wartenberg, Ahlame Saidi, Thomas Baranek, Serge Guyetant, Yves Courty, Oliver Eickelberg, Gilles Lalmanach, and Fabien Lecaille (2019): Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD. Am J Physiol Lung Cell Mol Physiol, in press. https://doi.org/10.1152/ajplung.00061.2019 [Project P07]

Yamina El Hamdaoui, Xiaosa Wu, Richard J. Clark, Julien Giribaldi, Raveendra Anangi, David J. Craik, Glenn F. King, Sebastien Dutertre, Quentin Kaas, Volker Herzig and Annette NickePeriplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR. Front. Pharmacol., 31 May 2019. https://doi.org/10.3389/fphar.2019.00577 [Project P01]

Alexander Dietrich. Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease. Pharmaceuticals (Basel), 1 February 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469169/ [Project P04]

Julia Herbert, Horst Thiermann, Franz Worek and Timo Wille. COPD and asthma therapeutics for supportive treatment in organophosphate poisoning. Clin Toxicol (Phila). 2019 Jul;57(7):644-651. doi: 10.1080/15563650.2018.1540785. [Project P02 & P03]

Merl-Pham J, Basak T, Knüppel L, Ramanujam D, Athanason M, Behr J, Engelhardt S, Eickelberg O, Hauck SM, Vanacore R, Staab-Weijnitz CA.  Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis; Matrix Biology Plus, 2019 Apr 09. https://doi.org/10.1016/j.mbplus.2019.04.002 [Project P06, P07 & P09]


Amelie Tsoutsoulopoulos, Markus Siegert, Harald John, Tabea Zubel, Aswin Mangerich, Annette Schmidt, Harald Mückter, Thomas Gudermann, Horst Thiermann, Dirk Steinritz, Tanja Popp. A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure. Chem Biol Interact. 2018 Nov 28;298:121-128. doi: 10.1016/j.cbi.2018.11.025[Project P03 & P10]